Three infections, one fight: an implementation study to map needle prevalence and evaluate HIV, syphilis and hepatitis C prevention interventions in Regina, Saskatchewan – a protocol
Introduction
Saskatchewan is currently experiencing a severe public health crisis marked by rising rates of HIV, syphilis, and hepatitis C infections, especially among people who inject drugs. Injection drug use fuels this overlapping epidemic, worsened by barriers like stigma, poverty, and lack of culturally safe healthcare. There is a pressing need for new, community-guided strategies to enhance prevention, testing, and access to treatment.
Methods and Analysis
The study will introduce a rapid assessment and response model in Regina, Saskatchewan, integrating geospatial mapping of needle distribution with community-driven outreach. Maps identifying needle hotspots will direct mobile pop-up clinics that provide on-site testing for HIV, syphilis, and HCV, as well as education on both pre-exposure (PrEP) and post-exposure prophylaxis (PEP).
A participatory mixed-methods design will evaluate the program’s feasibility, acceptance, and impact through the Reach, Effectiveness, Adoption, Implementation and Maintenance (RE-AIM) framework. Quantitative measures will track PrEP and PEP awareness, participant satisfaction, demographic patterns, and new diagnoses.
Qualitative Substudy
A nested qualitative study involving 30 participants will examine personal experiences with the intervention, perceived barriers to care, and views on service delivery quality. Insights from participants are expected to guide improvements in health program design and accessibility for marginalized communities.
Community engagement and evidence-based interventions aim to turn data into targeted prevention actions for populations most at risk.
Author Summary
This study integrates mapping, testing, and community outreach to address intertwined HIV, syphilis, and HCV epidemics in Regina through data-driven, culturally sensitive approaches.