NFL Picks and Predictions for Week 6
The NFL season continues with a highly anticipated slate of games in Week 6. Here are three plus-money bets to consider before kickoff.
By Spenser Davis, published on Oct 12, 2025.
Previous Performance
Last week's NFL bold predictions went 2-1, resulting in a total of +1.17 units. Since the start of Week 3, picks in this story are up 2.16 units.
This Week's Predictions
Here are three bold predictions for Week 6:
- Fading the Colts offense, despite their strong performance, averaging 3.39 points per drive, the highest this century if they maintain this pace.
"Fading the Colts offense is perhaps not the wisest choice, but I think there’s a case for doing so here."
Author's summary: NFL Week 6 predictions and picks.