Manchester United could be the most affected side when the 2025 TotalEnergies Africa Cup of Nations kicks off in December.
Manchester United will miss Amad Diallo (Ivory Coast), Bryan Mbeumo (Cameroon), and Noussair Mazroui (Morocco).
Andre Onana will also be in the Indomitable Lions squad come December.
Author's summary: Afcon 2025 affects Premier League teams.